Cruise to Sao Tome and Principe, an enchanting island nation off the coast of West Africa, famed for its biodiversity and unspoiled landscapes. Did you know Sao Tome and Principe is one of the smallest countries in Africa? Sao Tome and Principe cruises allow you to discover colonial architecture, indulge in fresh seafood, and explore lush cocoa plantations. Embark on a Sao Tome and Principe cruise voyage.